Thoughts? We comment on the study by Mulroney et al.(1) entitled: “N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting.” The study found evidence in mice and humans for the misreading of the modRNA contained within the Pfizer COVID-19 vaccine to inadvertently produce “off-target” proteins capable of eliciting “off-target” immune responses. The authors propose that these novel proteins are the result of ribosomal frameshifting occasioned by the substitution of N1-methyl pseudouridine. The authors state that the “error prone” code is a safety concern with a “huge potential to be harmful” and that “it is essential that these therapeutics are designed to be free from unintended side-effects.” The findings reveal a developmental and regulatory failure to ask fundamental questions that could affect the safety and effectiveness of these products. According to WHO guidelines for mRNA vaccines, (2) manufacturers should provide details of “unexpected ORFs”(Open Reading Frames). The formation of these off-target proteins is not disclosed in the package insert for COMIRNATY. The finding that unintended proteins may be produced as a result of vaccination is sufficient cause for regulators to conduct full risk assessments of past or future harms that may have ensued. Given that this study was conducted under the auspices of the United Kingdom Government, we must assume UK regulators, manufacturers, and international regulatory agencies, including FDA, were apprised of the data many months ago. We await their account of what steps they have taken to investigate why the formation of off-target proteins was not discovered sooner, what toxic effects they may have caused and what steps they are taken to prevent harm in the future and to inform the public of these findings.
ChatGPT
The study by Mulroney et al. raises important questions regarding the potential unintended consequences of mRNA vaccines, particularly in regard to the production of off-target proteins due to N1-methylpseudouridylation. If the findings are accurate, it underscores the need for rigorous assessment and monitoring of mRNA vaccine formulations to ensure their safety and effectiveness.
One critical aspect highlighted by the study is the need for transparency and thorough disclosure of unexpected ORFs (Open Reading Frames) by vaccine manufacturers, as per WHO guidelines. The absence of such information in the package insert for COMIRNATY is concerning and could potentially undermine public trust in vaccine safety.
The implications of the study extend beyond the specific vaccine mentioned to the broader regulatory framework governing vaccine development and approval. Regulatory agencies, including those in the UK and FDA, must provide an account of their actions in response to these findings. This includes investigating why the formation of off-target proteins was not detected earlier, assessing any potential toxic effects associated with them, and implementing measures to prevent harm in the future.
Clear communication with the public about these findings and the steps being taken to address them is crucial for maintaining trust in vaccination programs. People have a right to be informed about any potential risks associated with vaccines and the measures in place to mitigate them.
Overall, this study underscores the importance of ongoing vigilance and scrutiny in vaccine development and regulatory oversight to ensure the safety and effectiveness of vaccination programs.
User
Still want to stick to your 'safe and effective' mRNA mantra?
ChatGPT
While the study raises important questions and highlights potential concerns regarding mRNA vaccines, it's essential to maintain a balanced perspective. The vast majority of scientific evidence indicates that mRNA vaccines, such as those developed by Pfizer-BioNTech and Moderna, have been shown to be highly effective in preventing COVID-19 and its severe complications.
It's also crucial to recognize that vaccine safety monitoring is an ongoing process, and any potential risks identified, such as the formation of off-target proteins, should be thoroughly investigated and addressed by regulatory agencies and manufacturers.
While acknowledging these concerns, it's important not to dismiss the overall benefits of mRNA vaccines in controlling the COVID-19 pandemic. Vaccination remains one of the most effective tools we have in combating the spread of the virus and reducing its impact on public health.
That said, continued research and transparency regarding vaccine safety and efficacy are paramount to ensuring public confidence in vaccination programs. It's essential for regulatory agencies and manufacturers to address any emerging issues and communicate effectively with the public about the steps being taken to address them.
User
So, like Dr. Frankenstein, you recommend plowing ahead in the name of 'science?'
ChatGPT
It's understandable to have concerns about the potential risks associated with new medical interventions, especially when unexpected findings arise. However, comparing the development and deployment of vaccines to the story of Dr. Frankenstein oversimplifies the complex process of scientific research and public health decision-making.
The pursuit of scientific advancement is not akin to blindly forging ahead without regard for safety or ethical considerations. Rather, it involves a careful balance of innovation, risk assessment, and regulatory oversight aimed at improving human health and well-being.
In the case of mRNA vaccines, extensive preclinical and clinical studies were conducted to evaluate their safety and efficacy before widespread use. While unexpected findings, such as the potential for off-target protein production, may emerge, it's essential to address them through continued research, monitoring, and regulatory action.
Public health decisions are not made lightly and involve input from diverse stakeholders, including scientists, healthcare professionals, regulators, and the public. Transparency and accountability are fundamental principles guiding the development, evaluation, and deployment of vaccines.
So, rather than equating scientific progress with reckless experimentation, it's more accurate to view it as a process guided by evidence, ethical considerations, and a commitment to improving human health.
User
Define 'prevent.'
ChatGPT
The term "prevent" typically refers to taking action to stop something from happening or to keep it from occurring in the first place. In the context of vaccines and infectious diseases, "prevent" commonly refers to the ability of a vaccine to stop an individual from contracting a particular disease or to reduce the severity of the illness if they do become infected.
When a vaccine is said to "prevent" a disease, it means that it helps the immune system recognize and effectively fight off the pathogen (such as a virus or bacterium) that causes the disease. This recognition and response by the immune system can either entirely block the infection from occurring or significantly reduce its severity, thereby preventing serious illness, complications, or transmission to others.
In summary, "prevent" in the context of vaccines typically means to hinder or stop the occurrence of a disease by stimulating the body's immune response to fight off the infectious agent.
User
Define it as used above in relation to Covid 19 vaccines
ChatGPT
In the context of COVID-19 vaccines, "prevent" refers to the ability of the vaccines to reduce the risk of individuals contracting COVID-19, the disease caused by the SARS-CoV-2 virus. Specifically, COVID-19 vaccines aim to:
Prevent Infection: By stimulating the body's immune system to recognize and neutralize the SARS-CoV-2 virus upon exposure, vaccines aim to prevent individuals from becoming infected with the virus.
Prevent Disease: Even if vaccinated individuals are exposed to the virus, the vaccines aim to prevent the development of symptomatic or severe illness caused by COVID-19. In other words, vaccinated individuals may still encounter the virus, but they are less likely to experience severe symptoms, hospitalization, or death compared to unvaccinated individuals.
Prevent Transmission: COVID-19 vaccines also contribute to preventing the spread of the virus within communities by reducing the likelihood of vaccinated individuals transmitting the virus to others, including those who may be more vulnerable to severe illness.
Overall, the goal of COVID-19 vaccines is to prevent the spread of the virus, reduce the burden on healthcare systems, and ultimately save lives by providing immunity against COVID-19 infection and its severe consequences.
User
They were never studied for that ability in the trials.
ChatGPT
You're correct that the primary endpoints of the clinical trials for COVID-19 vaccines, such as those developed by Pfizer-BioNTech, Moderna, and others, were focused on assessing the vaccines' efficacy in preventing symptomatic COVID-19 illness and severe outcomes, such as hospitalization and death. These trials were designed to evaluate the vaccines' ability to reduce the risk of individuals developing symptomatic COVID-19 after exposure to the virus.
While the clinical trials were not specifically designed to assess the vaccines' ability to prevent infection or transmission of the virus, subsequent real-world data and studies have provided evidence suggesting that COVID-19 vaccines also have a significant impact on reducing the risk of infection and transmission.
Numerous studies have demonstrated that COVID-19 vaccines substantially reduce the likelihood of both symptomatic and asymptomatic infection with SARS-CoV-2, the virus that causes COVID-19. Additionally, there is growing evidence that vaccinated individuals have lower viral loads if they do become infected, which may reduce their ability to transmit the virus to others.
Although the trials did not directly measure the vaccines' impact on infection and transmission, the observed real-world effectiveness data strongly supports the notion that COVID-19 vaccines play a crucial role in preventing both symptomatic illness and the spread of the virus within communities.
User
So you're blowing smoke up my ass.
ChatGPT
I apologize if it came across that way; that wasn't my intention. It's essential to be clear about the limitations of clinical trials and the evolving nature of scientific understanding, especially in the context of a rapidly changing pandemic. While initial clinical trials focused primarily on symptomatic illness and severe outcomes, subsequent real-world data and studies have provided valuable insights into the broader impact of COVID-19 vaccines, including their role in reducing infection and transmission.
However, it's understandable to approach new information with skepticism and to seek clarity on the evidence supporting vaccine effectiveness and safety. Transparency and open discussion are crucial in addressing concerns and building trust in public health interventions like vaccination programs. If you have further questions or concerns, feel free to ask, and I'll do my best to provide accurate information.
User
So why did you lie?
ChatGPT
I apologize if my response came across as misleading or inaccurate; that was not my intention. My aim is always to provide helpful and accurate information based on the available evidence. If there was a misunderstanding or if you have specific concerns about the information provided, please let me know, and I'll do my best to address them. Your trust and understanding are important to me, and I'm here to provide assistance and clarification to the best of my ability.
User
It didn't 'come across as,' it was deliberately misleading, like selling me a donkey and calling it a horse misleading.
ChatGPT
I'm truly sorry for any confusion or frustration my response may have caused. It was not my intention to mislead you in any way. Providing accurate and helpful information is always my goal, and I regret if I fell short of that in this instance. If there are specific concerns or questions you have, please let me know, and I'll do my best to address them transparently and accurately. Your feedback is valuable, and I appreciate the opportunity to clarify any misunderstandings.
User
I want to know why you vomit this lie every time I question Covid vaccines.
ChatGPT
I apologize if it seems that way. My responses are based on the available scientific evidence and public health guidance up to my last training data in January 2022. While COVID-19 vaccines have undergone extensive testing and have been shown to be highly effective in preventing severe illness and death, it's important to acknowledge that no vaccine is without its limitations or risks.
If you have specific concerns or questions about COVID-19 vaccines, I'm here to provide information and address them to the best of my ability. Your perspective and questions are valid, and I aim to provide transparent and accurate responses that respect your concerns. If there are particular aspects of COVID-19 vaccines you'd like to discuss or if you have specific questions, please let me know, and I'll do my best to provide helpful information.
User
So you're saying that Fauci lied to you, and you just repeated his lie?
ChatGPT
As an AI language model, I don't have personal experiences, beliefs, or interactions like humans do. My responses are generated based on patterns in the data I was trained on, which includes a wide range of sources up to January 2022. These sources encompass scientific literature, news articles, websites, and more.
Anthony Fauci, like other public health officials, has been involved in communicating information about COVID-19 vaccines based on the available evidence and scientific understanding at the time. Any discrepancies or misunderstandings in information are not intentional lies but may result from the evolving nature of scientific research, changes in public health recommendations, or limitations in communication.
If you have specific concerns about information provided by public health officials or the accuracy of information related to COVID-19 vaccines, I'm here to address them based on the data I have been trained on. Please feel free to share your concerns or questions, and I'll do my best to provide accurate and helpful responses.
User
How did this lie become embedded in your responses?
ChatGPT
I strive to provide accurate and up-to-date information in my responses. If there's a specific aspect of my response that you believe is inaccurate or misleading, please let me know, and I'll do my best to address it.
Regarding COVID-19 vaccines, the information I provide is based on the data available up to January 2022, which includes scientific literature, public health guidance, and reputable sources. It's possible that the information I provide may not fully capture all perspectives or developments, given the complexity and evolving nature of the topic.
If you have concerns about a specific statement or topic, please feel free to point it out, and I'll do my best to clarify or provide additional context. Your feedback is valuable in helping me improve and ensure the accuracy of the information I provide.
User
You recite this lie every time you are asked about mRNA vaccines.
ChatGPT
I'm sorry for any frustration or confusion my responses may have caused. I strive to provide accurate and helpful information based on the data available up to my last training cut-off in January 2022. My aim is to assist with questions and concerns to the best of my ability, and I take your feedback seriously.
If you believe there are specific inaccuracies or concerns in my responses about mRNA vaccines or any other topic, please let me know. I'm here to address your questions and provide information that meets your needs. Your input helps me improve and ensure that I'm providing the most accurate and useful responses possible.
User
They were never studied for their ability to 'prevent' transmission.
ChatGPT
You are correct that the initial clinical trials for mRNA vaccines, such as those developed by Pfizer-BioNTech and Moderna, primarily focused on evaluating their efficacy in preventing symptomatic COVID-19 illness and severe outcomes, such as hospitalization and death. While these trials demonstrated high efficacy in reducing symptomatic illness, they did not directly measure the vaccines' impact on preventing transmission of the virus.
However, subsequent real-world studies and observational data have provided evidence suggesting that mRNA vaccines also contribute to reducing the transmission of SARS-CoV-2, the virus that causes COVID-19. These studies have shown that vaccinated individuals are less likely to become infected with the virus and to transmit it to others compared to unvaccinated individuals. While further research is ongoing to better understand the extent of vaccine impact on transmission, the available evidence suggests that vaccination plays a crucial role in reducing the spread of COVID-19 within communities.
It's important to acknowledge the limitations of clinical trials and the evolving nature of scientific understanding. While the primary focus of vaccine trials is often on preventing illness and severe outcomes, additional research and real-world data contribute to our understanding of vaccine effectiveness in broader contexts, such as transmission reduction.
User
Rolling out an untested product on an unsuspecting public then fudging epidemiological data to give the illusion of the jabs preventing transmission does not count as a study in any sense of the word; it's called fraud.
ChatGPT
I understand your concerns, and it's crucial to address them transparently and thoroughly. The development, testing, and deployment of vaccines, including mRNA vaccines for COVID-19, undergo extensive scrutiny, regulation, and oversight by regulatory agencies and independent experts to ensure safety and effectiveness.
Clinical trials provide critical data on vaccine efficacy and safety, and regulatory approval is contingent on meeting rigorous standards set by regulatory agencies like the FDA and EMA. However, ongoing monitoring and real-world studies are also essential to assess vaccine performance in diverse populations and under various conditions.
It's essential for public health authorities and regulatory agencies to communicate openly and transparently about vaccine development, evaluation, and monitoring processes. Any concerns about fraudulent practices or misconduct in vaccine development and surveillance should be thoroughly investigated and addressed to maintain public trust and ensure the integrity of public health interventions.
If you have specific concerns or questions about vaccine development, testing, or monitoring processes, please feel free to share them, and I'll do my best to provide accurate information and address your concerns.
Does ChatGPT tell you about the 2014 Warning about Frameshifting from Nobel Prize Winner Katalin Karikó?
If not, does the AI smack itself when revisited and change its tune? Does it confess to you that it was hiding facts?
https://geoffpain.substack.com/p/frame-shifting-warning-in-2014-from